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OCR: nKH, In contrast to intermittent injections of e leads to administration of GnRH at a constant ra 7). This reduced gonadotrophin secretion (Fig. 1 tion of phenomenon, attributed to down regula ne GnRH receptors, has been exploited for ty. In treatment of idiopathic precocious pube uper patients with this disorder, the use of a ' on to agonist' of GnRH inhibits gonadal funct o been prepubertal levels. This approach has al ents with used to suppress ovarian function in pa metastatic carcinoma of the breast and carcinomapituitary-testicular function in men wit of the prostate.